Intrinsically Self-renewing Neuroprogenitors From the A/J Mouse Spiral Ganglion as Virtually Unlimited Source of Mature Auditory Neurons

Intrinsically Self-renewing Neuroprogenitors From the A/J Mouse Spiral Ganglion as Virtually Unlimited Source of Mature Auditory Neurons

Nearly 460 million individuals are affected by sensorineural hearing loss (SNHL), one of the most common human sensory disorders. In mammals, hearing loss is permanent due to the lack of efficient regenerative capacity of the sensory epithelia and spiral ganglion neurons (SGN). Sphere-forming progen...

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Bibliographic Details
Main Authors: Francis Rousset, Vivianne B. C. Kokje, Rebecca Sipione, Dominik Schmidbauer, German Nacher-Soler, Sten Ilmjärv, Marta Coelho, Stefan Fink, François Voruz, Antoun El Chemaly, Antoine Marteyn, Hubert Löwenheim, Karl-Heinz Krause, Marcus Müller, Rudolf Glückert, Pascal Senn
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Cellular Neuroscience
Subjects:
cochlea
auditory neuron
regeneration
otic neurospheres
organoids
3R
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2020.599152/full

Internet

https://www.frontiersin.org/articles/10.3389/fncel.2020.599152/full

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