Plasmodium falciparum Liver Stage Infection and Transition to Stable Blood Stage Infection in Liver-Humanized and Blood-Humanized FRGN KO Mice Enables Testing of Blood Stage Inhibitory Antibodies (Reticulocyte-Binding Protein Homolog 5) In Vivo

Plasmodium falciparum Liver Stage Infection and Transition to Stable Blood Stage Infection in Liver-Humanized and Blood-Humanized FRGN KO Mice Enables Testing of Blood Stage Inhibitory Antibodies (Reticulocyte-Binding Protein Homolog 5) In Vivo

The invention of liver-humanized mouse models has made it possible to directly study the preerythrocytic stages of Plasmodium falciparum. In contrast, the current models to directly study blood stage infection in vivo are extremely limited. Humanization of the mouse blood stream is achievable by fre...

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Bibliographic Details
Main Authors: Lander Foquet, Carola Schafer, Nana K. Minkah, Daniel G. W. Alanine, Erika L. Flannery, Ryan W. J. Steel, Brandon K. Sack, Nelly Camargo, Matthew Fishbaugher, Will Betz, Thao Nguyen, Zachary P. Billman, Elizabeth M. Wilson, John Bial, Sean C. Murphy, Simon J. Draper, Sebastian A. Mikolajczak, Stefan H. I. Kappe
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-03-01
Series:Frontiers in Immunology
Subjects:
Plasmodium falciparum
humanized mouse model
Plasmodium falciparum blood stages
reticulocyte-binding protein homolog 5
clodronate liposomes
cyclophosphamide
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00524/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2018.00524/full

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