Brain-derived neurotrophic factor is required for axonal growth of selective groups of neurons in the arcuate nucleus

Brain-derived neurotrophic factor is required for axonal growth of selective groups of neurons in the arcuate nucleus

Objective: Brain-derived neurotrophic factor (BDNF) is a potent regulator of neuronal development, and the Bdnf gene produces two populations of transcripts with either a short or long 3′ untranslated region (3′ UTR). Deficiencies in BDNF signaling have been shown to cause severe obesity in humans;...

Full description

Bibliographic Details
Main Authors: Guey-Ying Liao, Karine Bouyer, Anna Kamitakahara, Niaz Sahibzada, Chien-Hua Wang, Michael Rutlin, Richard B. Simerly, Baoji Xu
Format: Article
Language:English
Published: Elsevier 2015-06-01
Series:Molecular Metabolism
Subjects:
TrkB
POMC neuron
AgRP neuron
Paraventricular hypothalamus
Excitatory synapse
Inhibitory synapse
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877815000587

Internet

http://www.sciencedirect.com/science/article/pii/S2212877815000587

Similar Items