Dabigatran mitigates cisplatin-mediated nephrotoxicity through down regulation of thrombin pathway

Dabigatran mitigates cisplatin-mediated nephrotoxicity through down regulation of thrombin pathway

Introduction: Cisplatin (CDDP) nephrotoxicity is one of the most significant complications limiting its use in cancer therapy. Objectives: This study investigated the pivotal role played by thrombin in CDDP-mediated nephrotoxicity. This work also aimed to clarify the possible preventive effect of Da...

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Bibliographic Details
Main Authors: Mohamed Gamal El-Din Ewees, Mohamed Sadek Abdel-Bakky, Asmaa Mostafa Ahmed Bayoumi, Ali Ahmed Abo-Saif, Waleed Mohammad Altowayan, Khalid Saad Alharbi, Basim Anwar Shehata Messiha
Format: Article
Language:English
Published: Elsevier 2021-07-01
Series:Journal of Advanced Research
Subjects:
Cisplatin
Dabigatran
Thrombin
pERK1/2
PAR2
Online Access:http://www.sciencedirect.com/science/article/pii/S2090123220302642

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http://www.sciencedirect.com/science/article/pii/S2090123220302642

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