Scalable Production of AAV Vectors in Orbitally Shaken HEK293 Cells

Adeno-associated virus (AAV) vectors are currently among the most commonly applied for in vivo gene therapy approaches. The evaluation of vectors during clinical development requires the production of considerable amounts of highly pure and potent vectors. Here, we set up a scalable process for AAV...

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Bibliographic Details
Main Authors: Daniel Blessing, Gabriel Vachey, Catherine Pythoud, Maria Rey, Vivianne Padrun, Florian M. Wurm, Bernard L. Schneider, Nicole Déglon
Format: Article
Language:English
Published: Elsevier 2019-06-01
Series:Molecular Therapy: Methods & Clinical Development
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050118301165