Murine HSCs contribute actively to native hematopoiesis but with reduced differentiation capacity upon aging

Murine HSCs contribute actively to native hematopoiesis but with reduced differentiation capacity upon aging

A hallmark of adult hematopoiesis is the continuous replacement of blood cells with limited lifespans. While active hematopoietic stem cell (HSC) contribution to multilineage hematopoiesis is the foundation of clinical HSC transplantation, recent reports have questioned the physiological contributio...

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Bibliographic Details
Main Authors: Petter Säwen, Mohamed Eldeeb, Eva Erlandsson, Trine A Kristiansen, Cecilia Laterza, Zaal Kokaia, Göran Karlsson, Joan Yuan, Shamit Soneji, Pankaj K Mandal, Derrick J Rossi, David Bryder
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-12-01
Series:eLife
Subjects:
hematopoiesis
stem cells
steady state
aging
lineage tracing
Online Access:https://elifesciences.org/articles/41258

Internet

https://elifesciences.org/articles/41258

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