Generation of Human Alloantigen-Specific Regulatory T Cells under Good Manufacturing Practice-Compliant Conditions for Cell Therapy

Natural regulatory T cells (Tregs) may have a great therapeutic potential to induce tolerance in allogeneic cells and organ transplantations. In mice, we showed that alloantigen-specific Tregs (spe-Tregs) were more efficient than polyclonal Tregs (poly-Tregs) in controlling graft-versus-host disease...

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Main Authors: Mustapha Chera, Yamina Hamel, Claude Baillou, Soumia Touil, Maude Guillot-Delost, Frédéric Charlotte, Laila Kossir, Ghislaine Simonin, Sébastien Maury, José L. Cohen, François M. Lemoine
Format: Article
Language:English
Published: SAGE Publishing 2015-12-01
Series:Cell Transplantation
Online Access:https://doi.org/10.3727/096368914X683566