Mitochondrial Ca2+ and membrane potential, an alternative pathway for Interleukin 6 to regulate CD4 cell effector function

Mitochondrial Ca2+ and membrane potential, an alternative pathway for Interleukin 6 to regulate CD4 cell effector function

IL-6 plays an important role in determining the fate of effector CD4 cells and the cytokines that these cells produce. Here we identify a novel molecular mechanism by which IL-6 regulates CD4 cell effector function. We show that IL-6-dependent signal facilitates the formation of mitochondrial respir...

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Bibliographic Details
Main Authors: Rui Yang, Dario Lirussi, Tina M Thornton, Dawn M Jelley-Gibbs, Sean A Diehl, Laure K Case, Muniswamy Madesh, Douglas J Taatjes, Cory Teuscher, Laura Haynes, Mercedes Rincón
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2015-05-01
Series:eLife
Subjects:
mitochondrion
IL-6
Stat3
calcium
effector cytokine
NFATc2
Online Access:https://elifesciences.org/articles/06376

Internet

https://elifesciences.org/articles/06376

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