The Association of Iron and the Pathologies of Parkinson’s Diseases in MPTP/MPP+-Induced Neuronal Degeneration in Non-human Primates and in Cell Culture

The Association of Iron and the Pathologies of Parkinson’s Diseases in MPTP/MPP+-Induced Neuronal Degeneration in Non-human Primates and in Cell Culture

Despite much efforts in the last few decades, the mechanism of degeneration of dopamine (DA) neurons in the substantia nigra (SN) in Parkinson’s disease (PD) remains unclear. This represents a major knowledge gap in idiopathic and genetic forms of PD. Among various possible key factors postulated, i...

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Bibliographic Details
Main Authors: Liangqin Shi, Chao Huang, Qihui Luo, Edmond Rogers, Yu Xia, Wentao Liu, Wenjing Ma, Wen Zeng, Li Gong, Jing Fang, Li Tang, Anchun Cheng, Riyi Shi, Zhengli Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-08-01
Series:Frontiers in Aging Neuroscience
Subjects:
Parkinson’s disease
iron
lipofuscin
oxidative stress
neuronal degeneration
rhesus monkey
Online Access:https://www.frontiersin.org/article/10.3389/fnagi.2019.00215/full

Internet

https://www.frontiersin.org/article/10.3389/fnagi.2019.00215/full

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