Potential impact of efflux pump genes in mediating rifampicin resistance in clinical isolates of Mycobacterium tuberculosis from India.

Potential impact of efflux pump genes in mediating rifampicin resistance in clinical isolates of Mycobacterium tuberculosis from India.

Despite the consideration of chromosomal mutations as the major cause of rifampicin (RIF) resistance in M. tuberculosis, the role of other mechanisms such as efflux pumps cannot be ruled out. We evaluated the role of four efflux pumps viz., MmpL2 (Rv0507), MmpL5 (Rv0676c), Rv0194 and Rv1250 in provi...

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Bibliographic Details
Main Authors: Anshika Narang, Kushal Garima, Shraddha Porwal, Archana Bhandekar, Kamal Shrivastava, Astha Giri, Naresh Kumar Sharma, Mridula Bose, Mandira Varma-Basil
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0223163

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https://doi.org/10.1371/journal.pone.0223163

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