Cys Site-Directed Mutagenesis of the Human SLC1A5 (ASCT2) Transporter: Structure/Function Relationships and Crucial Role of Cys467 for Redox Sensing and Glutamine Transport

Cys Site-Directed Mutagenesis of the Human SLC1A5 (ASCT2) Transporter: Structure/Function Relationships and Crucial Role of Cys467 for Redox Sensing and Glutamine Transport

The human plasma membrane transporter ASCT2 is responsible for mediating Na- dependent antiport of neutral amino acids. New insights into structure/function relationships were unveiled by a combined approach of recombinant over-expression, site-directed mutagenesis, transport assays in proteoliposom...

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Bibliographic Details
Main Authors: Mariafrancesca Scalise, Lorena Pochini, Lara Console, Gilda Pappacoda, Piero Pingitore, Kristina Hedfalk, Cesare Indiveri
Format: Article
Language:English
Published: MDPI AG 2018-02-01
Series:International Journal of Molecular Sciences
Subjects:
amino acid
glutamine
transport
over-expression
site-directed mutagenesis
liposome
Online Access:http://www.mdpi.com/1422-0067/19/3/648

Internet

http://www.mdpi.com/1422-0067/19/3/648

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