Hypusination Orchestrates the Antimicrobial Response of Macrophages

Hypusination Orchestrates the Antimicrobial Response of Macrophages

Summary: Innate responses of myeloid cells defend against pathogenic bacteria via inducible effectors. Deoxyhypusine synthase (DHPS) catalyzes the transfer of the N-moiety of spermidine to the lysine-50 residue of eukaryotic translation initiation factor 5A (EIF5A) to form the amino acid hypusine. H...

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Bibliographic Details
Main Authors: Alain P. Gobert, Jordan L. Finley, Yvonne L. Latour, Mohammad Asim, Thaddeus M. Smith, Thomas G. Verriere, Daniel P. Barry, Margaret M. Allaman, Alberto G. Delagado, Kristie L. Rose, M. Wade Calcutt, Kevin L. Schey, Johanna C. Sierra, M. Blanca Piazuelo, Raghavendra G. Mirmira, Keith T. Wilson
Format: Article
Language:English
Published: Elsevier 2020-12-01
Series:Cell Reports
Subjects:
macrophages
bacterial infection
innate immunity
hypusine
polyamines
Helicobacter pylori
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720314996

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http://www.sciencedirect.com/science/article/pii/S2211124720314996

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