Insulin signaling and dietary restriction differentially influence the decline of learning and memory with age.
Of all the age-related declines, memory loss is one of the most devastating. While conditions that increase longevity have been identified, the effects of these longevity-promoting factors on learning and memory are unknown. Here we show that the C. elegans Insulin/IGF-1 receptor mutant daf-2 improv...
Main Authors: | , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2010-05-01
|
Series: | PLoS Biology |
Online Access: | http://europepmc.org/articles/PMC2872642?pdf=render |
id |
doaj-c677c21359b6446cad513df00da03554 |
---|---|
record_format |
Article |
spelling |
doaj-c677c21359b6446cad513df00da035542021-07-02T03:59:28ZengPublic Library of Science (PLoS)PLoS Biology1544-91731545-78852010-05-0185e100037210.1371/journal.pbio.1000372Insulin signaling and dietary restriction differentially influence the decline of learning and memory with age.Amanda L KauffmanJasmine M AshrafM Ryan Corces-ZimmermanJessica N LandisColeen T MurphyOf all the age-related declines, memory loss is one of the most devastating. While conditions that increase longevity have been identified, the effects of these longevity-promoting factors on learning and memory are unknown. Here we show that the C. elegans Insulin/IGF-1 receptor mutant daf-2 improves memory performance early in adulthood and maintains learning ability better with age but, surprisingly, demonstrates no extension in long-term memory with age. By contrast, eat-2 mutants, a model of Dietary Restriction (DR), exhibit impaired long-term memory in young adulthood but maintain this level of memory longer with age. We find that crh-1, the C. elegans homolog of the CREB transcription factor, is required for long-term associative memory, but not for learning or short-term memory. The expression of crh-1 declines with age and differs in the longevity mutants, and CREB expression and activity correlate with memory performance. Our results suggest that specific longevity treatments have acute and long-term effects on cognitive functions that decline with age through their regulation of rate-limiting genes required for learning and memory.http://europepmc.org/articles/PMC2872642?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Amanda L Kauffman Jasmine M Ashraf M Ryan Corces-Zimmerman Jessica N Landis Coleen T Murphy |
spellingShingle |
Amanda L Kauffman Jasmine M Ashraf M Ryan Corces-Zimmerman Jessica N Landis Coleen T Murphy Insulin signaling and dietary restriction differentially influence the decline of learning and memory with age. PLoS Biology |
author_facet |
Amanda L Kauffman Jasmine M Ashraf M Ryan Corces-Zimmerman Jessica N Landis Coleen T Murphy |
author_sort |
Amanda L Kauffman |
title |
Insulin signaling and dietary restriction differentially influence the decline of learning and memory with age. |
title_short |
Insulin signaling and dietary restriction differentially influence the decline of learning and memory with age. |
title_full |
Insulin signaling and dietary restriction differentially influence the decline of learning and memory with age. |
title_fullStr |
Insulin signaling and dietary restriction differentially influence the decline of learning and memory with age. |
title_full_unstemmed |
Insulin signaling and dietary restriction differentially influence the decline of learning and memory with age. |
title_sort |
insulin signaling and dietary restriction differentially influence the decline of learning and memory with age. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS Biology |
issn |
1544-9173 1545-7885 |
publishDate |
2010-05-01 |
description |
Of all the age-related declines, memory loss is one of the most devastating. While conditions that increase longevity have been identified, the effects of these longevity-promoting factors on learning and memory are unknown. Here we show that the C. elegans Insulin/IGF-1 receptor mutant daf-2 improves memory performance early in adulthood and maintains learning ability better with age but, surprisingly, demonstrates no extension in long-term memory with age. By contrast, eat-2 mutants, a model of Dietary Restriction (DR), exhibit impaired long-term memory in young adulthood but maintain this level of memory longer with age. We find that crh-1, the C. elegans homolog of the CREB transcription factor, is required for long-term associative memory, but not for learning or short-term memory. The expression of crh-1 declines with age and differs in the longevity mutants, and CREB expression and activity correlate with memory performance. Our results suggest that specific longevity treatments have acute and long-term effects on cognitive functions that decline with age through their regulation of rate-limiting genes required for learning and memory. |
url |
http://europepmc.org/articles/PMC2872642?pdf=render |
work_keys_str_mv |
AT amandalkauffman insulinsignalinganddietaryrestrictiondifferentiallyinfluencethedeclineoflearningandmemorywithage AT jasminemashraf insulinsignalinganddietaryrestrictiondifferentiallyinfluencethedeclineoflearningandmemorywithage AT mryancorceszimmerman insulinsignalinganddietaryrestrictiondifferentiallyinfluencethedeclineoflearningandmemorywithage AT jessicanlandis insulinsignalinganddietaryrestrictiondifferentiallyinfluencethedeclineoflearningandmemorywithage AT coleentmurphy insulinsignalinganddietaryrestrictiondifferentiallyinfluencethedeclineoflearningandmemorywithage |
_version_ |
1721340940206997504 |