A novel extracellular Hsp90 mediated co-receptor function for LRP1 regulates EphA2 dependent glioblastoma cell invasion.

A novel extracellular Hsp90 mediated co-receptor function for LRP1 regulates EphA2 dependent glioblastoma cell invasion.

Extracellular Hsp90 protein (eHsp90) potentiates cancer cell motility and invasion through a poorly understood mechanism involving ligand mediated function with its cognate receptor LRP1. Glioblastoma multiforme (GBM) represents one of the most aggressive and lethal brain cancers. The receptor tyros...

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Bibliographic Details
Main Authors: Udhayakumar Gopal, Jessica E Bohonowych, Carla Lema-Tome, Angen Liu, Elizabeth Garrett-Mayer, Bingcheng Wang, Jennifer S Isaacs
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-03-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3050925?pdf=render

Internet

http://europepmc.org/articles/PMC3050925?pdf=render

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