Modulation of MDR1 and MRP3 Gene Expression in Lung Cancer Cells after Paclitaxel and Carboplatin Exposure

Modulation of MDR1 and MRP3 Gene Expression in Lung Cancer Cells after Paclitaxel and Carboplatin Exposure

Carboplatin-paclitaxel is a reference regimen in the treatment of locally advanced or disseminated non-small cell lung cancer (NSCLC). This paper discusses the multidrug resistance developed with this drug combination, which is one of the major obstacles to successful treatment. In order to understa...

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Bibliographic Details
Main Authors: Consolación Melguizo, Jose Prados, Raquel Luque, Raúl Ortiz, Octavio Caba, Pablo J. Álvarez, Beatriz Gonzalez, Antonia Aranega
Format: Article
Language:English
Published: MDPI AG 2012-12-01
Series:International Journal of Molecular Sciences
Subjects:
lung cancer
resistance
MDR
MRP
paclitaxel
carboplatin
Online Access:http://www.mdpi.com/1422-0067/13/12/16624

Internet

http://www.mdpi.com/1422-0067/13/12/16624

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