Antifibrotic effect of xanthohumol in combination with praziquantel is associated with altered redox status and reduced iron accumulation during liver fluke-associated cholangiocarcinogenesis

Antifibrotic effect of xanthohumol in combination with praziquantel is associated with altered redox status and reduced iron accumulation during liver fluke-associated cholangiocarcinogenesis

Cholangiocarcinoma (CCA) caused by infection of the liver fluke Opisthorchis viverrini, (Ov) is the major public health problem in northeast Thailand. Following Ov infection the subsequent molecular changes can be associated by reactive oxygen species (ROS) induced chronic inflammation, advanced per...

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Bibliographic Details
Main Authors: Wassana Jamnongkan, Malinee Thanee, Puangrat Yongvanit, Watcharin Loilome, Raynoo Thanan, Phongsaran Kimawaha, Tidarat Boonmars, Runglawan Silakit, Nisana Namwat, Anchalee Techasen
Format: Article
Language:English
Published: PeerJ Inc. 2018-01-01
Series:PeerJ
Subjects:
Cholangiocarcinoma
Oxidative stress
DNA damage
Iron
Chemoprevention
Fibrosis
Online Access:https://peerj.com/articles/4281.pdf

Internet

https://peerj.com/articles/4281.pdf

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