Tomato lycopene extract prevents lipopolysaccharide-induced NF-kappaB signaling but worsens dextran sulfate sodium-induced colitis in NF-kappaBEGFP mice.

Tomato lycopene extract prevents lipopolysaccharide-induced NF-kappaB signaling but worsens dextran sulfate sodium-induced colitis in NF-kappaBEGFP mice.

The impact of tomato lycopene extract (TLE) on intestinal inflammation is currently unknown. We investigated the effect of TLE on lipopolysaccharide (LPS)-induced innate signaling and experimental colitis.Mice were fed a diet containing 0.5 and 2% TLE or isoflavone free control (AIN-76). The therape...

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Bibliographic Details
Main Authors: Young-Eun Joo, Thomas Karrasch, Marcus Mühlbauer, Brigitte Allard, Acharan Narula, Hans H Herfarth, Christian Jobin
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2642995?pdf=render

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http://europepmc.org/articles/PMC2642995?pdf=render

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