Nuclear bodies reorganize during myogenesis in vitro and are differentially disrupted by expression of FSHD-associated DUX4

Nuclear bodies reorganize during myogenesis in vitro and are differentially disrupted by expression of FSHD-associated DUX4

Abstract Background Nuclear bodies, such as nucleoli, PML bodies, and SC35 speckles, are dynamic sub-nuclear structures that regulate multiple genetic and epigenetic processes. Additional regulation is provided by RNA/DNA handling proteins, notably TDP-43 and FUS, which have been linked to ALS patho...

Full description

Bibliographic Details
Main Authors: Sachiko Homma, Mary Lou Beermann, Bryant Yu, Frederick M. Boyce, Jeffrey Boone Miller
Format: Article
Language:English
Published: BMC 2016-12-01
Series:Skeletal Muscle
Subjects:
DUX4
FUS
Facioscapulohumeral muscular dystrophy
Myotube
Nucleoli
PML bodies
Online Access:http://link.springer.com/article/10.1186/s13395-016-0113-7

Internet

http://link.springer.com/article/10.1186/s13395-016-0113-7

Similar Items