Cyclin-Dependent Kinase 9 (CDK9) Inhibitor Atuveciclib Suppresses Intervertebral Disk Degeneration via the Inhibition of the NF-κB Signaling Pathway

Cyclin-Dependent Kinase 9 (CDK9) Inhibitor Atuveciclib Suppresses Intervertebral Disk Degeneration via the Inhibition of the NF-κB Signaling Pathway

Intervertebral disk degeneration (IVDD) is a spinal disk condition caused by an inflammatory response induced by various proinflammatory cytokines, such as interleukin (IL)-1β and tumor necrosis factor (TNF)-α. cyclin-dependent kinase 9 (CDK9) is a transcriptional regulator and potential therapeutic...

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Bibliographic Details
Main Authors: Weiyu Ni, Feizhou Zhang, Lin Zheng, Lili Wang, Yi Liang, Yuhong Ding, Jasper H. N. Yik, Dominik R. Haudenschild, Shunwu Fan, Ziang Hu
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
intervertebral disk degeneration
nucleus pulposus
CDK9
extracellular matrix
atuveciclib
ex vivo
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2020.579658/full

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https://www.frontiersin.org/article/10.3389/fcell.2020.579658/full

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