A universal system for highly efficient cardiac differentiation of human induced pluripotent stem cells that eliminates interline variability.

The production of cardiomyocytes from human induced pluripotent stem cells (hiPSC) holds great promise for patient-specific cardiotoxicity drug testing, disease modeling, and cardiac regeneration. However, existing protocols for the differentiation of hiPSC to the cardiac lineage are inefficient and...

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Bibliographic Details
Main Authors: Paul W Burridge, Susan Thompson, Michal A Millrod, Seth Weinberg, Xuan Yuan, Ann Peters, Vasiliki Mahairaki, Vassilis E Koliatsos, Leslie Tung, Elias T Zambidis
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-04-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3072973?pdf=render