Inhibition of kinesin-5 improves regeneration of injured axons by a novel microtubule-based mechanism

Inhibition of kinesin-5 improves regeneration of injured axons by a novel microtubule-based mechanism

Microtubules have been identified as a powerful target for augmenting regeneration of injured adult axons in the central nervous system. Drugs that stabilize microtubules have shown some promise, but there are concerns that abnormally stabilizing microtubules may have only limited benefits for regen...

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Bibliographic Details
Main Authors: Peter W Baas, Andrew J Matamoros
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2015-01-01
Series:Neural Regeneration Research
Subjects:
microtubule
axon
kinesin-5
Eg5
regeneration
monastrol
molecular motor protein
Online Access:http://www.nrronline.org/article.asp?issn=1673-5374;year=2015;volume=10;issue=6;spage=845;epage=849;aulast=Baas

Internet

http://www.nrronline.org/article.asp?issn=1673-5374;year=2015;volume=10;issue=6;spage=845;epage=849;aulast=Baas

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