Secreted protein acidic and rich in cysteine (SPARC) exacerbates colonic inflammatory symptoms in dextran sodium sulphate-induced murine colitis.

Secreted protein acidic and rich in cysteine (SPARC) exacerbates colonic inflammatory symptoms in dextran sodium sulphate-induced murine colitis.

BACKGROUND: Secreted Protein Acidic and Rich in Cysteine (SPARC) is expressed during tissue repair and regulates cellular proliferation, migration and cytokine expression. The aim was to determine if SPARC modifies intestinal inflammation. METHODS: Wild-type (WT) and SPARC-null (KO) mice received 3%...

Full description

Bibliographic Details
Main Authors: Yoke-Leng Ng, Borut Klopcic, Frances Lloyd, Cynthia Forrest, Wayne Greene, Ian C Lawrance
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3804578?pdf=render

Internet

http://europepmc.org/articles/PMC3804578?pdf=render

Similar Items