Enhancing Fatty Acid Catabolism of Macrophages Within Aberrant Breast Cancer Tumor Microenvironment Can Re-establish Antitumor Function

Enhancing Fatty Acid Catabolism of Macrophages Within Aberrant Breast Cancer Tumor Microenvironment Can Re-establish Antitumor Function

Triple-negative breast cancer (TNBC) remains an intractable challenge owing to its aggressive nature and lack of any known therapeutic targets. Macrophages play a crucial role in cancer promotion and poor prognosis within the tumor microenvironment (TME). The phagocytosis checkpoint in macrophages h...

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Bibliographic Details
Main Authors: Yucui Gu, Xingjian Niu, Lei Yin, Yiran Wang, Yue Yang, Xudong Yang, Qingyuan Zhang, Hongfei Ji
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
triple-negative breast cancer
tumor metabolic microenvironment
macrophages
fatty acid catabolism
peroxisome proliferator-activated receptor alpha
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.665869/full

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https://www.frontiersin.org/articles/10.3389/fcell.2021.665869/full

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