Covalent Histone Modification by an Electrophilic Derivative of the Anti-HIV Drug Nevirapine

Covalent Histone Modification by an Electrophilic Derivative of the Anti-HIV Drug Nevirapine

Nevirapine (NVP), a non-nucleoside reverse transcriptase inhibitor widely used in combined antiretroviral therapy and to prevent mother-to-child transmission of the human immunodeficiency virus type 1, is associated with several adverse side effects. Using 12-mesyloxy-nevirapine, a model electrophil...

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Bibliographic Details
Main Authors: Shrika G. Harjivan, Catarina Charneira, Inês L. Martins, Sofia A. Pereira, Guadalupe Espadas, Eduard Sabidó, Frederick A. Beland, M. Matilde. Marques, Alexandra M.M. Antunes
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Molecules
Subjects:
covalent histone modification
mass spectrometry
drug-induced adverse reactions
covalent protein adducts
nevirapine
Online Access:https://www.mdpi.com/1420-3049/26/5/1349

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https://www.mdpi.com/1420-3049/26/5/1349

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