Gene Expression Landscape of SDH-Deficient Gastrointestinal Stromal Tumors

Gene Expression Landscape of SDH-Deficient Gastrointestinal Stromal Tumors

Background: About 20–40% of gastrointestinal stromal tumors (GISTs) lacking KIT/PDGFRA mutations show defects in succinate dehydrogenase (SDH) complex. This study uncovers the gene expression profile (GEP) of SDH-deficient GIST in order to identify new signaling pathways or molecular events actionab...

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Bibliographic Details
Main Authors: Valentina Indio, Angela Schipani, Margherita Nannini, Milena Urbini, Alessandro Rizzo, Antonio De De Leo, Annalisa Altimari, Valerio Di Di Scioscio, Daria Messelodi, Giuseppe Tarantino, Annalisa Astolfi, Maria Abbondanza Pantaleo
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Journal of Clinical Medicine
Subjects:
SDH-deficient
gastrointestinal stromal tumor
GIST
fibroblast growth factor receptor
hypoxia
pheochromocytoma/paraganglioma
Online Access:https://www.mdpi.com/2077-0383/10/5/1057

Internet

https://www.mdpi.com/2077-0383/10/5/1057

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