The Diabetes-Linked Transcription Factor PAX4: From Gene to Functional Consequences

The Diabetes-Linked Transcription Factor PAX4: From Gene to Functional Consequences

Paired box 4 (PAX4) is a key factor in the generation of insulin producing β-cells during embryonic development. In adult islets, PAX4 expression is sequestered to a subset of β-cells that are prone to proliferation and more resistant to stress-induced apoptosis. The importance of this transcription...

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Bibliographic Details
Main Authors: Petra I. Lorenzo, Francisco Juárez-Vicente, Nadia Cobo-Vuilleumier, Mario García-Domínguez, Benoit R. Gauthier
Format: Article
Language:English
Published: MDPI AG 2017-03-01
Series:Genes
Subjects:
PAX4
transcription regulation
SUMOylation
diabetes mellitus
β-cell adaptation
regenerative therapy
Online Access:http://www.mdpi.com/2073-4425/8/3/101

Internet

http://www.mdpi.com/2073-4425/8/3/101

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