Genetic background modifies vulnerability to glaucoma-related phenotypes in Lmx1b mutant mice
Variants in the LIM homeobox transcription factor 1-beta (LMX1B) gene predispose individuals to elevated intraocular pressure (IOP), a key risk factor for glaucoma. However, the effect of LMX1B mutations varies widely between individuals. To better understand the mechanisms underlying LMX1B-related...
Main Authors: | , , , , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
The Company of Biologists
2021-02-01
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Series: | Disease Models & Mechanisms |
Subjects: | |
Online Access: | http://dmm.biologists.org/content/14/2/dmm046953 |