Tissue-Specific Effects of Reduced β-catenin Expression on Adenomatous Polyposis Coli Mutation-Instigated Tumorigenesis in Mouse Colon and Ovarian Epithelium.

Tissue-Specific Effects of Reduced β-catenin Expression on Adenomatous Polyposis Coli Mutation-Instigated Tumorigenesis in Mouse Colon and Ovarian Epithelium.

Adenomatous polyposis coli (APC) inactivating mutations are present in most human colorectal cancers and some other cancers. The APC protein regulates the β-catenin protein pool that functions as a co-activator of T cell factor (TCF)-regulated transcription in Wnt pathway signaling. We studied effec...

Full description

Bibliographic Details
Main Authors: Ying Feng, Naoya Sakamoto, Rong Wu, Jie-Yu Liu, Alexandra Wiese, Maranne E Green, Megan Green, Aytekin Akyol, Badal C Roy, Yali Zhai, Kathleen R Cho, Eric R Fearon
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-11-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC4631511?pdf=render

Internet

http://europepmc.org/articles/PMC4631511?pdf=render

Similar Items