Real-time imaging of HIF-1alpha stabilization and degradation.

Real-time imaging of HIF-1alpha stabilization and degradation.

HIF-1alpha is overexpressed in many human cancers compared to normal tissues due to the interaction of a multiplicity of factors and pathways that reflect specific genetic alterations and extracellular stimuli. We developed two HIF-1alpha chimeric reporter systems, HIF-1alpha/FLuc and HIF-1alpha(Del...

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Bibliographic Details
Main Authors: Ekaterina Moroz, Sean Carlin, Katerina Dyomina, Sean Burke, Howard T Thaler, Ronald Blasberg, Inna Serganova
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2660410?pdf=render

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http://europepmc.org/articles/PMC2660410?pdf=render

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