Naringenin Ameliorates Drosophila ReepA Hereditary Spastic Paraplegia-Linked Phenotypes

Naringenin Ameliorates Drosophila ReepA Hereditary Spastic Paraplegia-Linked Phenotypes

Defects in the endoplasmic reticulum (ER) membrane shaping and interaction with other organelles seem to be a crucial mechanism underlying Hereditary Spastic Paraplegia (HSP) neurodegeneration. REEP1, a transmembrane protein belonging to TB2/HVA22 family, is implicated in SPG31, an autosomal dominan...

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Bibliographic Details
Main Authors: Barbara Napoli, Sentiljana Gumeni, Alessia Forgiarini, Marianna Fantin, Concetta De Filippis, Elena Panzeri, Chiara Vantaggiato, Genny Orso
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Neuroscience
Subjects:
endoplasmic reticulum
hereditary spastic paraplegia
naringenin
REEP1
ReepA
UPR
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2019.01202/full

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https://www.frontiersin.org/article/10.3389/fnins.2019.01202/full

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