The Role of Heme Oxygenase 1 in the Protective Effect of Caloric Restriction against Diabetic Cardiomyopathy

The Role of Heme Oxygenase 1 in the Protective Effect of Caloric Restriction against Diabetic Cardiomyopathy

Type 2 diabetes mellitus (DM2) leads to cardiomyopathy characterized by cardiomyocyte hypertrophy, followed by mitochondrial dysfunction and interstitial fibrosis, all of which are exacerbated by angiotensin II (AT). SIRT1 and its transcriptional coactivator target PGC-1α (peroxisome prolif...

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Bibliographic Details
Main Authors: Maayan Waldman, Vadim Nudelman, Asher Shainberg, Romy Zemel, Ran Kornwoski, Dan Aravot, Stephen J. Peterson, Michael Arad, Edith Hochhauser
Format: Article
Language:English
Published: MDPI AG 2019-05-01
Series:International Journal of Molecular Sciences
Subjects:
caloric restriction
Sirtuin 1
Heme Oxygenase-1
PGC-1α
cardiomyopathy
diabetes mellitus
Online Access:https://www.mdpi.com/1422-0067/20/10/2427

Internet

https://www.mdpi.com/1422-0067/20/10/2427

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