Unified Cox model based multifactor dimensionality reduction method for gene-gene interaction analysis of the survival phenotype

Unified Cox model based multifactor dimensionality reduction method for gene-gene interaction analysis of the survival phenotype

Abstract Background One strategy for addressing missing heritability in genome-wide association study is gene-gene interaction analysis, which, unlike a single gene approach, involves high-dimensionality. The multifactor dimensionality reduction method (MDR) has been widely applied to reduce multi-l...

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Bibliographic Details
Main Authors: Seungyeoun Lee, Donghee Son, Yongkang Kim, Wenbao Yu, Taesung Park
Format: Article
Language:English
Published: BMC 2018-12-01
Series:BioData Mining
Subjects:
Survival time
Cox model
Multifactor dimensionality reduction method
Gene-gene interaction
Unified model based method
Online Access:http://link.springer.com/article/10.1186/s13040-018-0189-1

Internet

http://link.springer.com/article/10.1186/s13040-018-0189-1

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