Early motor deficits in mouse disease models are reliably uncovered using an automated home-cage wheel-running system: a cross-laboratory validation

Deficits in motor function are debilitating features in disorders affecting neurological, neuromuscular and musculoskeletal systems. Although these disorders can vary greatly with respect to age of onset, symptomatic presentation, rate of progression and severity, the study of these disease models i...

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Bibliographic Details
Main Authors: Silvia Mandillo, Ines Heise, Luciana Garbugino, Glauco P. Tocchini-Valentini, Alessandro Giuliani, Sara Wells, Patrick M. Nolan
Format: Article
Language:English
Published: The Company of Biologists 2014-03-01
Series:Disease Models & Mechanisms
Subjects:
Online Access:http://dmm.biologists.org/content/7/3/397