Extracellular Vesicles Enriched with Moonlighting Metalloproteinase Are Highly Transmissive, Pro-Tumorigenic, and Trans-Activates Cellular Communication Network Factor (<i>CCN2/CTGF</i>): CRISPR against Cancer

Extracellular Vesicles Enriched with Moonlighting Metalloproteinase Are Highly Transmissive, Pro-Tumorigenic, and Trans-Activates Cellular Communication Network Factor (<i>CCN2/CTGF</i>): CRISPR against Cancer

Matrix metalloproteinase 3 (MMP3) plays multiple roles in extracellular proteolysis as well as intracellular transcription, prompting a new definition of moonlighting metalloproteinase (MMP), according to a definition of protein moonlighting (or gene sharing), a phenomenon by which a protein can per...

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Bibliographic Details
Main Authors: Yuka Okusha, Takanori Eguchi, Manh T. Tran, Chiharu Sogawa, Kaya Yoshida, Mami Itagaki, Eman A. Taha, Kisho Ono, Eriko Aoyama, Hirohiko Okamura, Ken-ichi Kozaki, Stuart K. Calderwood, Masaharu Takigawa, Kuniaki Okamoto
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Cancers
Subjects:
matrix metalloproteinase
moonlighting metalloproteinase (MMP)
protein moonlighting
transcription factor
extracellular vesicles
oncosome
Online Access:https://www.mdpi.com/2072-6694/12/4/881

Internet

https://www.mdpi.com/2072-6694/12/4/881

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