Immune-Mediated Mechanisms in Cofactor-Dependent Food Allergy and Anaphylaxis: Effect of Cofactors in Basophils and Mast Cells
Cofactors may explain why in some cases food ingestion leads to anaphylaxis while in others elicits a milder reaction or tolerance. With cofactors, reactions become more severe and/or have a lower allergen threshold. Cofactors are present in up to 58% of food anaphylaxis (FAn). Exercise, NSAIDs, and...
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Frontiers Media S.A.
2021-02-01
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Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2020.623071/full |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Rosa Muñoz-Cano Rosa Muñoz-Cano Rosa Muñoz-Cano Rosa Muñoz-Cano Clara San Bartolome Clara San Bartolome Clara San Bartolome Rocío Casas-Saucedo Rocío Casas-Saucedo Rocío Casas-Saucedo Giovanna Araujo Giovanna Araujo Sonia Gelis Sonia Gelis Maria Ruano-Zaragoza Maria Ruano-Zaragoza Maria Ruano-Zaragoza Jordi Roca-Ferrer Jordi Roca-Ferrer Jordi Roca-Ferrer Francis Palomares Francis Palomares Margarita Martin Margarita Martin Margarita Martin Joan Bartra Joan Bartra Joan Bartra Joan Bartra Mariona Pascal Mariona Pascal Mariona Pascal |
spellingShingle |
Rosa Muñoz-Cano Rosa Muñoz-Cano Rosa Muñoz-Cano Rosa Muñoz-Cano Clara San Bartolome Clara San Bartolome Clara San Bartolome Rocío Casas-Saucedo Rocío Casas-Saucedo Rocío Casas-Saucedo Giovanna Araujo Giovanna Araujo Sonia Gelis Sonia Gelis Maria Ruano-Zaragoza Maria Ruano-Zaragoza Maria Ruano-Zaragoza Jordi Roca-Ferrer Jordi Roca-Ferrer Jordi Roca-Ferrer Francis Palomares Francis Palomares Margarita Martin Margarita Martin Margarita Martin Joan Bartra Joan Bartra Joan Bartra Joan Bartra Mariona Pascal Mariona Pascal Mariona Pascal Immune-Mediated Mechanisms in Cofactor-Dependent Food Allergy and Anaphylaxis: Effect of Cofactors in Basophils and Mast Cells Frontiers in Immunology mast cell basophil adenosin NSAID cofactor exercise |
author_facet |
Rosa Muñoz-Cano Rosa Muñoz-Cano Rosa Muñoz-Cano Rosa Muñoz-Cano Clara San Bartolome Clara San Bartolome Clara San Bartolome Rocío Casas-Saucedo Rocío Casas-Saucedo Rocío Casas-Saucedo Giovanna Araujo Giovanna Araujo Sonia Gelis Sonia Gelis Maria Ruano-Zaragoza Maria Ruano-Zaragoza Maria Ruano-Zaragoza Jordi Roca-Ferrer Jordi Roca-Ferrer Jordi Roca-Ferrer Francis Palomares Francis Palomares Margarita Martin Margarita Martin Margarita Martin Joan Bartra Joan Bartra Joan Bartra Joan Bartra Mariona Pascal Mariona Pascal Mariona Pascal |
author_sort |
Rosa Muñoz-Cano |
title |
Immune-Mediated Mechanisms in Cofactor-Dependent Food Allergy and Anaphylaxis: Effect of Cofactors in Basophils and Mast Cells |
title_short |
Immune-Mediated Mechanisms in Cofactor-Dependent Food Allergy and Anaphylaxis: Effect of Cofactors in Basophils and Mast Cells |
title_full |
Immune-Mediated Mechanisms in Cofactor-Dependent Food Allergy and Anaphylaxis: Effect of Cofactors in Basophils and Mast Cells |
title_fullStr |
Immune-Mediated Mechanisms in Cofactor-Dependent Food Allergy and Anaphylaxis: Effect of Cofactors in Basophils and Mast Cells |
title_full_unstemmed |
Immune-Mediated Mechanisms in Cofactor-Dependent Food Allergy and Anaphylaxis: Effect of Cofactors in Basophils and Mast Cells |
title_sort |
immune-mediated mechanisms in cofactor-dependent food allergy and anaphylaxis: effect of cofactors in basophils and mast cells |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Immunology |
issn |
1664-3224 |
publishDate |
2021-02-01 |
description |
Cofactors may explain why in some cases food ingestion leads to anaphylaxis while in others elicits a milder reaction or tolerance. With cofactors, reactions become more severe and/or have a lower allergen threshold. Cofactors are present in up to 58% of food anaphylaxis (FAn). Exercise, NSAIDs, and alcohol are the most frequently described, although the underlying mechanisms are poorly known. Several hypotheses have suggested the influence of these cofactors on basophils and mast cells (MCs). Exercise has been suggested to enhance MC activation by increasing plasma osmolarity, redistributing blood flow, and activating adenosine and eicosanoid metabolism. NSAIDs’ cofactor effect has been related with cyclooxygenase inhibition and therefore, prostaglandin E2 (PGE2) production. Indeed, overexpression of adenosine receptor 3 (A3) gene has been described in NSAID-dependent FAn; A3 activation potentiates FcϵRI-induced MC degranulation. Finally, alcohol has been related with an increase of histamine levels by inhibition of diamino oxidase (DAO) and also with and increase of extracellular adenosine by inhibition of its uptake. However, most of these mechanisms have limited evidence, and further studies are urgently needed. In conclusion, the study of the immune-related mechanisms involved in food allergic reactions enhanced by cofactors is of the utmost interest. This knowledge will help to design both tailored treatments and prophylactic strategies that, nowadays, are non-existent. |
topic |
mast cell basophil adenosin NSAID cofactor exercise |
url |
https://www.frontiersin.org/articles/10.3389/fimmu.2020.623071/full |
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doaj-c6d0937bcefa4542ac97a8a1eba47ac72021-02-17T05:27:29ZengFrontiers Media S.A.Frontiers in Immunology1664-32242021-02-011110.3389/fimmu.2020.623071623071Immune-Mediated Mechanisms in Cofactor-Dependent Food Allergy and Anaphylaxis: Effect of Cofactors in Basophils and Mast CellsRosa Muñoz-Cano0Rosa Muñoz-Cano1Rosa Muñoz-Cano2Rosa Muñoz-Cano3Clara San Bartolome4Clara San Bartolome5Clara San Bartolome6Rocío Casas-Saucedo7Rocío Casas-Saucedo8Rocío Casas-Saucedo9Giovanna Araujo10Giovanna Araujo11Sonia Gelis12Sonia Gelis13Maria Ruano-Zaragoza14Maria Ruano-Zaragoza15Maria Ruano-Zaragoza16Jordi Roca-Ferrer17Jordi Roca-Ferrer18Jordi Roca-Ferrer19Francis Palomares20Francis Palomares21Margarita Martin22Margarita Martin23Margarita Martin24Joan Bartra25Joan Bartra26Joan Bartra27Joan Bartra28Mariona Pascal29Mariona Pascal30Mariona Pascal31Allergy Section, Pneumology Department, Institut Clinic Respiratori (ICR), Hospital Clinic, Barcelona, SpainAsma, Reacciones Adversas y Alergia (ARADyAL), Instituto de Salud Carlos III, Madrid, SpainImmunoalergia Respiratoria y Experimental - Institut d'Investigacions Biomediques August Pi i Sunyer (IRCE-IDIBAPS), Barcelona, SpainUniversitat de Barcelona, Barcelona, SpainAsma, Reacciones Adversas y Alergia (ARADyAL), Instituto de Salud Carlos III, Madrid, SpainImmunoalergia Respiratoria y Experimental - Institut d'Investigacions Biomediques August Pi i Sunyer (IRCE-IDIBAPS), Barcelona, SpainImmunology Department, Centre de Diagnostic Biomedic (CDB), Hospital Clínic, Barcelona, SpainAllergy Section, Pneumology Department, Institut Clinic Respiratori (ICR), Hospital Clinic, Barcelona, SpainAsma, Reacciones Adversas y Alergia (ARADyAL), Instituto de Salud Carlos III, Madrid, SpainImmunoalergia Respiratoria y Experimental - Institut d'Investigacions Biomediques August Pi i Sunyer (IRCE-IDIBAPS), Barcelona, SpainAllergy Section, Pneumology Department, Institut Clinic Respiratori (ICR), Hospital Clinic, Barcelona, SpainImmunoalergia Respiratoria y Experimental - Institut d'Investigacions Biomediques August Pi i Sunyer (IRCE-IDIBAPS), Barcelona, SpainAllergy Section, Pneumology Department, Institut Clinic Respiratori (ICR), Hospital Clinic, Barcelona, SpainImmunoalergia Respiratoria y Experimental - Institut d'Investigacions Biomediques August Pi i Sunyer (IRCE-IDIBAPS), Barcelona, SpainAllergy Section, Pneumology Department, Institut Clinic Respiratori (ICR), Hospital Clinic, Barcelona, SpainAsma, Reacciones Adversas y Alergia (ARADyAL), Instituto de Salud Carlos III, Madrid, SpainImmunoalergia Respiratoria y Experimental - Institut d'Investigacions Biomediques August Pi i Sunyer (IRCE-IDIBAPS), Barcelona, SpainImmunoalergia Respiratoria y Experimental - Institut d'Investigacions Biomediques August Pi i Sunyer (IRCE-IDIBAPS), Barcelona, SpainUniversitat de Barcelona, Barcelona, SpainCentro de Investigaciones Biomédicas en Red de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, Madrid, SpainAsma, Reacciones Adversas y Alergia (ARADyAL), Instituto de Salud Carlos III, Madrid, SpainAllergy Research Group, Instituto de Investigación Biomédica de Málaga-IBIMA, Málaga, SpainAsma, Reacciones Adversas y Alergia (ARADyAL), Instituto de Salud Carlos III, Madrid, SpainImmunoalergia Respiratoria y Experimental - Institut d'Investigacions Biomediques August Pi i Sunyer (IRCE-IDIBAPS), Barcelona, SpainBiochemistry Unit, University of Barcelona Faculty of Medicine and Health Sciences, Barcelona, SpainAllergy Section, Pneumology Department, Institut Clinic Respiratori (ICR), Hospital Clinic, Barcelona, SpainAsma, Reacciones Adversas y Alergia (ARADyAL), Instituto de Salud Carlos III, Madrid, SpainImmunoalergia Respiratoria y Experimental - Institut d'Investigacions Biomediques August Pi i Sunyer (IRCE-IDIBAPS), Barcelona, SpainUniversitat de Barcelona, Barcelona, SpainAsma, Reacciones Adversas y Alergia (ARADyAL), Instituto de Salud Carlos III, Madrid, SpainImmunoalergia Respiratoria y Experimental - Institut d'Investigacions Biomediques August Pi i Sunyer (IRCE-IDIBAPS), Barcelona, SpainImmunology Department, Centre de Diagnostic Biomedic (CDB), Hospital Clínic, Barcelona, SpainCofactors may explain why in some cases food ingestion leads to anaphylaxis while in others elicits a milder reaction or tolerance. With cofactors, reactions become more severe and/or have a lower allergen threshold. Cofactors are present in up to 58% of food anaphylaxis (FAn). Exercise, NSAIDs, and alcohol are the most frequently described, although the underlying mechanisms are poorly known. Several hypotheses have suggested the influence of these cofactors on basophils and mast cells (MCs). Exercise has been suggested to enhance MC activation by increasing plasma osmolarity, redistributing blood flow, and activating adenosine and eicosanoid metabolism. NSAIDs’ cofactor effect has been related with cyclooxygenase inhibition and therefore, prostaglandin E2 (PGE2) production. Indeed, overexpression of adenosine receptor 3 (A3) gene has been described in NSAID-dependent FAn; A3 activation potentiates FcϵRI-induced MC degranulation. Finally, alcohol has been related with an increase of histamine levels by inhibition of diamino oxidase (DAO) and also with and increase of extracellular adenosine by inhibition of its uptake. However, most of these mechanisms have limited evidence, and further studies are urgently needed. In conclusion, the study of the immune-related mechanisms involved in food allergic reactions enhanced by cofactors is of the utmost interest. This knowledge will help to design both tailored treatments and prophylactic strategies that, nowadays, are non-existent.https://www.frontiersin.org/articles/10.3389/fimmu.2020.623071/fullmast cellbasophiladenosinNSAIDcofactorexercise |