Expression of CD39 on Activated T Cells Impairs their Survival in Older Individuals

Expression of CD39 on Activated T Cells Impairs their Survival in Older Individuals

Summary: In an immune response, CD4+ T cells expand into effector T cells and then contract to survive as long-lived memory cells. To identify age-associated defects in memory cell formation, we profiled activated CD4+ T cells and found an increased induction of the ATPase CD39 with age. CD39+ CD4+...

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Bibliographic Details
Main Authors: Fengqin Fang, Mingcan Yu, Mary M. Cavanagh, Jessica Hutter Saunders, Qian Qi, Zhongde Ye, Sabine Le Saux, William Sultan, Emerson Turgano, Cornelia L. Dekker, Lu Tian, Cornelia M. Weyand, Jörg J. Goronzy
Format: Article
Language:English
Published: Elsevier 2016-02-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716000061

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http://www.sciencedirect.com/science/article/pii/S2211124716000061

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