Developmental Rewiring between Cerebellar Climbing Fibers and Purkinje Cells Begins with Positive Feedback Synapse Addition

Summary: During postnatal development, cerebellar climbing fibers alter their innervation strengths onto supernumerary Purkinje cell targets, generating a one-to-few connectivity pattern in adulthood. To get insight about the processes responsible for this remapping, we reconstructed serial electron...

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Bibliographic Details
Main Authors: Alyssa Michelle Wilson, Richard Schalek, Adi Suissa-Peleg, Thouis R. Jones, Seymour Knowles-Barley, Hanspeter Pfister, Jeff William Lichtman
Format: Article
Language:English
Published: Elsevier 2019-11-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124719314032