Janus Kinase Inhibitor Baricitinib Modulates Human Innate and Adaptive Immune System

Janus Kinase Inhibitor Baricitinib Modulates Human Innate and Adaptive Immune System

The purpose of this study was to elucidate the mechanism of action of baricitinib on Janus kinase (JAK)/signal transducer and activator of transcription (STAT) signaling, which involves in human innate and adaptive immune system. The effects of baricitinib were evaluated using human monocyte-derived...

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Bibliographic Details
Main Authors: Satoshi Kubo, Shingo Nakayamada, Kei Sakata, Yukihiro Kitanaga, Xiaoxue Ma, Seunghyun Lee, Akina Ishii, Kaoru Yamagata, Kazuhisa Nakano, Yoshiya Tanaka
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-06-01
Series:Frontiers in Immunology
Subjects:
baricitinib
tofacitinib
Janus kinase
signal transducer and activator of transcription
human immunology
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01510/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.01510/full

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