Inhibition of BET Proteins Reduces Right Ventricle Hypertrophy and Pulmonary Hypertension Resulting from Combined Hypoxia and Pulmonary Inflammation

Inhibition of BET Proteins Reduces Right Ventricle Hypertrophy and Pulmonary Hypertension Resulting from Combined Hypoxia and Pulmonary Inflammation

Pulmonary hypertension is a co-morbidity, which strongly participates in morbi-mortality in patients with chronic obstructive pulmonary disease (COPD). Recent findings showed that bromodomain-containing proteins, in charge of reading histone acetylation, could be involved in pulmonary arterial hyper...

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Bibliographic Details
Main Authors: Clovis Chabert, Saadi Khochbin, Sophie Rousseaux, Sylvie Veyrenc, Rebecca Furze, Nicholas Smithers, Rab K Prinjha, Uwe Schlattner, Christophe Pison, Hervé Dubouchaud
Format: Article
Language:English
Published: MDPI AG 2018-07-01
Series:International Journal of Molecular Sciences
Subjects:
Epigenetic
COPD
pulmonary hypertension
hypoxia
pulmonary inflammation
Online Access:http://www.mdpi.com/1422-0067/19/8/2224

Internet

http://www.mdpi.com/1422-0067/19/8/2224

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