Prophylactic antigen‐specific T‐cells targeting seven viral and fungal pathogens after allogeneic haemopoietic stem cell transplant

Prophylactic antigen‐specific T‐cells targeting seven viral and fungal pathogens after allogeneic haemopoietic stem cell transplant

Abstract Objectives Adoptive immunotherapy using donor‐derived antigen‐specific T‐cells can prevent and treat infection after allogeneic haemopoietic stem cell transplant (HSCT). Methods We treated 11 patients with a prophylactic infusion of 2 × 107 cells per square metre donor‐derived T‐cells targe...

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Bibliographic Details
Main Authors: David Jonathan Gottlieb, Leighton Edward Clancy, Barbara Withers, Helen Marie McGuire, Fabio Luciani, Mandeep Singh, Brendan Hughes, Brian Gloss, David Kliman, Chun Kei Kris Ma, Shyam Panicker, David Bishop, Ming‐Celine Dubosq, Ziduo Li, Selmir Avdic, Kenneth Micklethwaite, Emily Blyth
Format: Article
Language:English
Published: Wiley 2021-01-01
Series:Clinical & Translational Immunology
Subjects:
adoptive immunotherapy
allogeneic stem cell transplantation
CTL
haemopoietic stem cell transplant
opportunistic infection
systemic fungal infection
Online Access:https://doi.org/10.1002/cti2.1249

Internet

https://doi.org/10.1002/cti2.1249

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