Loss of Cln5 causes altered neurogenesis in a mouse model of a childhood neurodegenerative disorder

Loss of Cln5 causes altered neurogenesis in a mouse model of a childhood neurodegenerative disorder

Neural stem/progenitor cells (NPCs) generate new neurons in the brain throughout an individual's lifetime in an intricate process called neurogenesis. Neurogenic alterations are a common feature of several adult-onset neurodegenerative diseases. The neuronal ceroid lipofuscinoses (NCLs) are the...

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Bibliographic Details
Main Authors: Ekaterina Savchenko, Yajuvinder Singh, Henna Konttinen, Katarina Lejavova, Laura Mediavilla Santos, Alexandra Grubman, Virve Kärkkäinen, Velta Keksa-Goldsteine, Nikolay Naumenko, Pasi Tavi, Anthony R. White, Tarja Malm, Jari Koistinaho, Katja M. Kanninen
Format: Article
Language:English
Published: The Company of Biologists 2017-09-01
Series:Disease Models & Mechanisms
Subjects:
Neurogenesis
Neuronal ceroid lipofuscinoses
Batten disease
Lysosomal storage disease
Stem cells
CLN5
Online Access:http://dmm.biologists.org/content/10/9/1089

Internet

http://dmm.biologists.org/content/10/9/1089

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