Association of leukocyte DNA methylation changes with dietary folate and alcohol intake in the EPIC study

Association of leukocyte DNA methylation changes with dietary folate and alcohol intake in the EPIC study

Abstract Background There is increasing evidence that folate, an important component of one-carbon metabolism, modulates the epigenome. Alcohol, which can disrupt folate absorption, is also known to affect the epigenome. We investigated the association of dietary folate and alcohol intake on leukocy...

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Main Authors: F. Perrier, V. Viallon, S. Ambatipudi, A. Ghantous, C. Cuenin, H. Hernandez-Vargas, V. Chajès, L. Baglietto, M. Matejcic, H. Moreno-Macias, T. Kühn, H. Boeing, A. Karakatsani, A. Kotanidou, A. Trichopoulou, S. Sieri, S. Panico, F. Fasanelli, M. Dolle, C. Onland-Moret, I. Sluijs, E. Weiderpass, J. R. Quirós, A. Agudo, J. M. Huerta, E. Ardanaz, M. Dorronsoro, T. Y. N. Tong, K. Tsilidis, E. Riboli, M. J. Gunter, Z. Herceg, P. Ferrari, I. Romieu
Format: Article
Language:English
Published: BMC 2019-04-01
Series:Clinical Epigenetics
Subjects:
DNA methylation
Dietary folate
Alcohol intake
DMR
Fused lasso
EPIC cohort
Online Access:http://link.springer.com/article/10.1186/s13148-019-0637-x

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http://link.springer.com/article/10.1186/s13148-019-0637-x

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