Escape of TLR5 Recognition by Leptospira spp.: A Rationale for Atypical Endoflagella

Escape of TLR5 Recognition by Leptospira spp.: A Rationale for Atypical Endoflagella

Leptospira (L.) interrogans are invasive bacteria responsible for leptospirosis, a worldwide zoonosis. They possess two periplasmic endoflagellae that allow their motility. L. interrogans are stealth pathogens that escape the innate immune recognition of the NOD-like receptors NOD1/2, and the human...

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Bibliographic Details
Main Authors: Marion Holzapfel, Delphine Bonhomme, Julie Cagliero, Frédérique Vernel-Pauillac, Martine Fanton d’Andon, Sophia Bortolussi, Laurence Fiette, Cyrille Goarant, Elsio A. Wunder, Mathieu Picardeau, Albert I. Ko, Dirk Werling, Mariko Matsui, Ivo G. Boneca, Catherine Werts
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Immunology
Subjects:
Leptospira
toll-like receptor
innate immunity
Flagelin genes
TLR5
mouse model
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.02007/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.02007/full

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