An interpretable bimodal neural network characterizes the sequence and preexisting chromatin predictors of induced transcription factor binding
Abstract Background Transcription factor (TF) binding specificity is determined via a complex interplay between the transcription factor’s DNA binding preference and cell type-specific chromatin environments. The chromatin features that correlate with transcription factor binding in a given cell typ...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2021-01-01
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| Series: | Genome Biology |
| Online Access: | https://doi.org/10.1186/s13059-020-02218-6 |