Glycyrrhizin Inhibits Interleukin-8 Production and Nuclear Factor–κ B Activity in Lung Epithelial Cells, but Not Through Glucocorticoid Receptors

This study was designed to examine the glucocorticoid-like inhibitory effect of glycyrrhizin (GL) on interleukin (IL)-8 production in A549 lung epithelial cells. GL, as well as dexamethasone (DEX) inhibited both tumor necrosis factor (TNF)-α –and IL-1β –induced IL-8 production, mRNA expression, and...

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Bibliographic Details
Main Authors: Hironori Takei, Yuichiro Baba, Akinori Hisatsune, Hiroshi Katsuki, Takeshi Miyata, Kazumi Yokomizo, Yoichiro Isohama
Format: Article
Language:English
Published: Elsevier 2008-01-01
Series:Journal of Pharmacological Sciences
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861319315051