Variation in CYP2A6 Activity and Personalized Medicine

Variation in CYP2A6 Activity and Personalized Medicine

The cytochrome P450 2A6 (CYP2A6) enzyme metabolizes several clinically relevant substrates, including nicotine—the primary psychoactive component in cigarette smoke. The gene that encodes the CYP2A6 enzyme is highly polymorphic, resulting in extensive interindividual variation in CYP2A6 enzyme activ...

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Bibliographic Details
Main Authors: Julie-Anne Tanner, Rachel F. Tyndale
Format: Article
Language:English
Published: MDPI AG 2017-12-01
Series:Journal of Personalized Medicine
Subjects:
pharmacogenetics
pharmacogenomics
drug metabolism
CYP2A6
smoking
nicotine
genetic variation
SNP
inhibitor
inducer
Online Access:https://www.mdpi.com/2075-4426/7/4/18

Internet

https://www.mdpi.com/2075-4426/7/4/18

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