Development of novel rifampicin-derived P-glycoprotein activators/inducers. synthesis, in silico analysis and application in the RBE4 cell model, using paraquat as substrate.

Development of novel rifampicin-derived P-glycoprotein activators/inducers. synthesis, in silico analysis and application in the RBE4 cell model, using paraquat as substrate.

P-glycoprotein (P-gp) is a 170 kDa transmembrane protein involved in the outward transport of many structurally unrelated substrates. P-gp activation/induction may function as an antidotal pathway to prevent the cytotoxicity of these substrates. In the present study we aimed at testing rifampicin (R...

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Bibliographic Details
Main Authors: Vânia Vilas-Boas, Renata Silva, Andreia Palmeira, Emília Sousa, Luísa Maria Ferreira, Paula Sério Branco, Félix Carvalho, Maria de Lourdes Bastos, Fernando Remião
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23991219/?tool=EBI

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https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23991219/?tool=EBI

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