Genetic inhibition of CaMKII in dorsal striatal medium spiny neurons reduces functional excitatory synapses and enhances intrinsic excitability.

Genetic inhibition of CaMKII in dorsal striatal medium spiny neurons reduces functional excitatory synapses and enhances intrinsic excitability.

Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) is abundant in striatal medium spiny neurons (MSNs). CaMKII is dynamically regulated by changes in dopamine signaling, as occurs in Parkinson's disease as well as addiction. Although CaMKII has been extensively studied in the hippocampus wh...

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Bibliographic Details
Main Authors: Jason R Klug, Brian N Mathur, Thomas L Kash, Hui-Dong Wang, Robert T Matthews, A J Robison, Mark E Anderson, Ariel Y Deutch, David M Lovinger, Roger J Colbran, Danny G Winder
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3448631?pdf=render

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http://europepmc.org/articles/PMC3448631?pdf=render

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