Resistance to the Tat Inhibitor Didehydro-Cortistatin A Is Mediated by Heightened Basal HIV-1 Transcription

Resistance to the Tat Inhibitor Didehydro-Cortistatin A Is Mediated by Heightened Basal HIV-1 Transcription

HIV-1 Tat enhances viral RNA transcription by binding to TAR and recruiting activating factors. Tat enhances its own transcription via a positive-feedback loop. Didehydro-cortistatin A (dCA) is a potent Tat inhibitor, reducing HIV-1 transcription and preventing viral rebound. dCA activity demonstrat...

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Bibliographic Details
Main Authors: Guillaume Mousseau, Rachna Aneja, Mark A. Clementz, Sonia Mediouni, Noemia S. Lima, Alexander Haregot, Cari F. Kessing, Joseph A. Jablonski, Suzie Thenin-Houssier, Nisha Nagarsheth, Lydie Trautmann, Susana T. Valente
Format: Article
Language:English
Published: American Society for Microbiology 2019-07-01
Series:mBio
Subjects:
hiv promoter
hiv transcription
nef
tat inhibitor
vpr
drug resistance
viral resistance
Online Access:https://doi.org/10.1128/mBio.01750-18

Internet

https://doi.org/10.1128/mBio.01750-18

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