Characterization of the Signaling Modalities of Prostaglandin E2 Receptors EP2 and EP4 Reveals Crosstalk and a Role for Microtubules

Characterization of the Signaling Modalities of Prostaglandin E2 Receptors EP2 and EP4 Reveals Crosstalk and a Role for Microtubules

Prostaglandin E2 (PGE2) is a lipid mediator that modulates the function of myeloid immune cells such as macrophages and dendritic cells (DCs) through the activation of the G protein-coupled receptors EP2 and EP4. While both EP2 and EP4 signaling leads to an elevation of intracellular cyclic adenosin...

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Bibliographic Details
Main Authors: Ward Vleeshouwers, Koen van den Dries, Sandra de Keijzer, Ben Joosten, Diane S. Lidke, Alessandra Cambi
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Immunology
Subjects:
membrane receptor
prostaglandin E2 signaling
myeloid cells
G protein-coupled receptor
podosome
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.613286/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2020.613286/full

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